By Gerald G. Briggs, etc.
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Extra resources for Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk
A 2013 case report described the outcome of a pregnancy exposed to abatacept in the 1st trimester (7). A 33-year-old woman with rheumatoid arthritis conceived while receiving abatacept (10 mg/kg every 4 weeks) and methotrexate (15 mg/week). 5 weeks’. Both drugs were stopped, but a daily 5 mg dose of an unspecified corticosteroid was allowed. At 40 weeks’, the woman gave birth vaginally to a healthy 3180-g infant (sex not specified) with Apgar scores of 10 and 10 at 5 and 10 minutes, respectively.
Update on safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs. Rheumatology 2008;47(Suppl 3):iii28–31. Ostensen M, Förger F. Management of RA medications in pregnant patients. Nat Rev Rheumatol 2009;5:382–90. Makol A, Wright K, Amin S. Rheumatoid arthritis and pregnancy—safety considerations in pharmacological management. Drugs 2011;71:1973–87. Pham T, Bachelez H, Barthelot JM, Blacher J, Claudepierre P, Constantin A, Fautrel B, Gaujoux-Viala C, Goeb V, Gossec L, Goupille P, Guillaume-Czitrom S, Hachulla E, Lequerre T, Marolleau JP, Martinez V, Masson C, Mouthon L, Puechal X, Richette P, Saraux A, Schaeverbeke T, Soubrier M, Viguier M, Vittecoq O, Wendling D, Mariette X, Sibilia J.
Antiretroviral Pregnancy Registry Steering Committee. Antiretroviral Pregnancy Registry International Interim Report for 1 January 1989 through 31 July 2009. Wilmington, NC: Registry Coordinating Center; 2009. com. Accessed May 29, 2010. Carpenter CCJ, Fischi MA, Hammer SM, Hirsch MS, Jacobsen DM, Katzenstein DA, Montaner JSG, Richman DD, Saag MS, Schooley RT, Thompson MA, Vella S, Yeni PG, Volberding PA. Antiretroviral therapy for HIV infection in 1996. JAMA 1996;276:146–54. Minkoff H, Augenbraun M.