By Binghe Wang, Longqin Hu, Teruna J. Siahaan
An crucial device for these operating on the entrance strains of recent drug developmentWritten for busy execs on the leading edge of recent drug improvement, Drug supply will get readers fast on top of things on either the rules and newest functions within the more and more very important box of drug delivery.Recent advancements in such components as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' skill to speedily establish and synthesize new pharmacological compounds. even if, delivery-related houses stay an important reason behind medical trial failures.Bringing jointly contributions by way of best foreign specialists, Drug supply covers the full box in a scientific yet concise method. It starts with an in-depth evaluation of key basics, equivalent to physiochemical and organic limitations; drug supply pathways; metabolism; drug formula; pharmacokinetic and pharmacodynamic concerns; and extra. the rest of the ebook is dedicated to the systematic examination-including overviews, well timed examples, and large references-of a bunch of particular matters, including:* Receptor-mediated drug supply* Prodrug supply methods* Oral protein and peptide drug supply* Gene remedy and gene supply* Ultrasound-mediated drug supply* Polycationic peptides and proteins in drug supply* Pulmonary drug supply* Antibody-directed drug supply* Efflux transporters in drug excretion* highbrow estate matters in drug supply
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Extra info for Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development)
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