Dendritic Cells: Biology and Clinical Applications by Michael T. Lotze, Angus W. Thomson

By Michael T. Lotze, Angus W. Thomson

Dendritic Cells, second variation is the hot version of the tremendous profitable e-book released in 1998. With the quantity of literature on dendritic cells doubling each year, it's virtually very unlikely to take care of. This publication presents the main updated synthesis of the literature, written by way of the superior authors. it's crucial interpreting for any scientist operating in immunology, phone biology, infectious ailments, melanoma, transplantation, genetic engineering, or the pharmaceutical/biotechnology undefined. * a wholly new part on DC biology is integrated during this variation. additionally new to this version are chapters on:* Imaging* interplay of dendritic cells with viruses* Dendritic cells and dendrikines, chemokines and the endothelium* Molecules expressed in dendritic cells* function of dendritic cells in wound therapeutic and atherosclerosis* supply of apoptotic our bodies* Genetic engineering of dendritic cells* Imaging* useful points of scientific protocol improvement

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The transcription factor PU-1 is essential for the formation of B cells, monocyte/ macrophages and is required only for the formation of putative myeloid-related DCs. Thus specific molecular events provide distinct cues in developing hematopoietic cells that control the formation of separate populations of DCs. 02 Spitze_Lotze & Thompson 0791 16/7/01 10:13 am C H Page 13 A P T E R 2 Dendritic cells in the thymus Hergen Spits Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands What does not destroy me, makes me strong.

As Mac-1 is a myeloid marker, the data of Rodewald suggest that the murine thymus may contain myeloid-related DCs in addition to lymphoidrelated DCs. ORIGIN AND MOLECULAR BIOLOGY OF DENDRITIC CELLS 02 Spitze_Lotze & Thompson 0791 16/7/01 10:13 am Page 19 19 REFERENCES Human CD34ϩCD1aϪ thymic precursors also have the capacity to develop into two types of DC, suggesting that different DC subsets can exist in human thymus. , 1995, 1998). Many of these cells also express CD1a. When the CD34ϩCD1aϪ cells are co-cultured with the S17 stromal cells, some of the cells develop into CD123hi DC precursors that develop into mature DC following culture with IL-3 and CD40L (H.

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