By Anthony R. Mire-Sluis, Robin Thorpe
This booklet presents accomplished insurance of the cytokines from a pharmacological technique. The chapters are provided in a constant structure permitting effortless cross-reference, with pattern diagrams and a precis desk of crucial proof for every bankruptcy on the finish of the book.Cytokines is exclusive in stressing cytokine biology and the applying of analysis info to supply illness remedy. With 33 targeted and updated chapters approximately person cytokines, this entire reference will offer either clinicians and researchers in immunology and pharmacology with beneficial info. Key positive aspects* Genetic details and sequences* Protein constitution* mobilephone resources and construction* organic job* Cytokine receptor constitution and sign transduction* dialogue of the position of cytokines in ailment and the possibility of treatment* precis desk of crucial proof* complete bibliography
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Extra info for Cytokines (Handbook of Immunopharmacology)
Immunol. Today, 15,562. , et al. ( 1 9 9 4 b ) . IL-13 induces expression and release of the IL-1 decoy receptor in human polymorphonuclear cells. J. Biol. Chem. 269, 12403. , Matteucci, C. and Mantovani, A. (1995). Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells. J. Exp. Med. 181, 2181. , et al. (1996). Regulated expression and release of the interleukin-1 decoy receptor in human mononuclear phagocytes. J. Immunol. 156, 2534. W.
Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation. Blood 81, 1347. E. and Mantovani, A. (1994a). The type II "decoy" receptor: novel regulatory pathway for interleukin-1. Immunol. Today, 15,562. , et al. ( 1 9 9 4 b ) . IL-13 induces expression and release of the IL-1 decoy receptor in human polymorphonuclear cells. J. Biol. Chem. 269, 12403. , Matteucci, C. and Mantovani, A. (1995). Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.
MANTOVANI biological activity. The two cysteine residues oflL-1~ are essential for activity, whereas exposed lysines are not critical. Mutation studies indicated that arginine 4, leucine 6, threonine 9, arginine 11, histidine 30 and aspartic acid 146 are important for biological activity. Arginine 120 is also important either in stabilizing the tertiary structure or in the interaction with the receptor. , 1990). , 1990). 2), secreted both in unglycosylated (18 kDa) and glycosylated (22 kDa) forms.