Controlled-Release Technology. Pharmaceutical Applications by Ping I. Lee and William R. Good (Eds.)

By Ping I. Lee and William R. Good (Eds.)

content material: assessment of controlled-release drug supply / Ping I. Lee and William R. reliable --
Microstructural versions for diffusive shipping in porous polymers / W. Mark Saltzman, Stephen H. Pasternak, and Robert Langer --
Diffusion in heterogeneous media / Bret Berner, J.C. Keister, and Eugene R. Cooper --
Estimation of charges of drug diffusion in polymers / C.G. Pitt, A.L. Andrady, Y.T. Bao, and N.K.P. Samuel --
Interpretation of drug-release kinetics from hydrogel matrices when it comes to time-dependent diffusion coefficients / Ping I. Lee --
Physicochemical types for percutaneous absorption / J. Hadgraft and Richard H. man --
floor chemical research of polymeric drug supply platforms through static secondary ion mass spectrometry (SSIMS) and SIMS imaging / M.C. Davies and A. Brown --
better strategy for measuring in vitro diffusion of substances via human dermis / L.R. Brown, J.F. Cline, C.L. Raleigh, and M.B. Henry --
Simplified process for measuring controlled-release kinetics / Charles G. Gebelein, Tahseen Mirza, and Robert R. Hartsough --
Thermally reversible gelation features : poly(oxyethylene)-poly(oxypropylene) block copolymer in aqueous resolution after publicity to high-energy irradiation / D. Attwood, C.J. Tait, and J.H. Collett --
unlock and behind schedule liberate of water-soluble medicinal drugs from polymer beads with low water swelling / Karl F. Mueller --
Morphine hydrogel suppositories : machine layout, scale-up, and overview / Marion E. McNeill and Neil B. Graham --
Use of bioerodible polymers in self-regulated drug supply structures / J. Heller, S.H. Pangburn, and D.W.H. Penhale --
Polysaccharides as drug providers : activation tactics and biodegradation reports / Etienne Schacht, Filip Vandoorne, Joan Vermeersch, and Ruth Duncan --
Microspheres as controlled-release structures for parenteral and nasal management / S.S. Davis, L. Illum, D. Burgess, J. Ratcliffe, and S.N. generators --
improving drug unencumber from polylactide microspheres through the use of base within the microencapsulation method / Jones W. Fong, Hawkins V. Maulding, George E. Visscher, Josephine P. Nazareno, and Jane E. Pearson --
results of ethanol at the shipping of [beta]-estradiol in hairless mouse dermis : comparability of experimental info with a brand new theoretical version / W.I. Higuchi, U.D. Rohr, S.A. Burton, P. Liu, J.L. Fox, A.H. Ghanem, H. Mahmoud, S. Borsadia, and William R. strong --
Probing the constitution of stratum corneum at the molecular point / ok. Knutson, S.L. Krill, W.J. Lambert, and W.I. Higuchi --
New liposomal supply procedure for managed drug unencumber / Victoria M. Knepp, Robert S. Hinz, Francis C. Szoka, Jr., and Richard H. man --
more suitable absorption of ionizable medicines from topical dosage types / Tsuneji Nagai and Toyoaki Ishikura --
Transdermal drug supply approach with greater dermis permeability / Yei W. Chien and Chia-Shun Lee --
solution to improve intranasal peptide supply / Lawrence S. Olanoff and Richard E. Gibson --
Transbuccal absorption of diclofenac sodium in a puppy version / C.D. Ebert, V.A. John, P.T. Beall, and K.A. Rosenzweig --
Constant-release diffusion structures : fee regulate through geometric configuration / K.G. Nelson, S.J. Smith, and R.M. Bennett --
Disposable controlled-release gadget for drug infusion / Paul Y. Wang, Mary C.Y. Lee, and should S.M. Smith.

Show description

Read or Download Controlled-Release Technology. Pharmaceutical Applications PDF

Best pharmacy books

Free Energy Calculations in Rational Drug Design

Unfastened strength calculations signify the main exact computational procedure to be had for predicting enzyme inhibitor binding affinities. Advances in desktop strength within the Nineteen Nineties enabled the sensible program of those calculations in motive drug layout. This ebook represents the 1st complete evaluate of this transforming into zone of analysis and covers the elemental thought underlying the tactic, a number of state-of-the-art ideas designed to enhance throughput and dozen examples in which loose power calculations have been used to layout and evaluation capability drug applicants.

Fundamentals of Medicinal Chemistry

Applicable basically for pharmacy scholars, this undergraduate textbook introduces the elemental chemical rules and techniques utilized in drug discovery and layout with no requiring an in depth biology history. Later chapters describe the pharmacokinetics and metabolism of substances, and description the levels within the drug improvement procedure.

Supramolecular Chemistry: From Biological Inspiration to Biomedical Applications

Supramolecular chemistry is usually defined because the research of chemistry past the straightforward molecular point but it's always forgotten what number of the pioneering su-pramolecular chemists seemed to molecular biology for his or her principles. the hunt for an aldolase enzyme mimic, the invention of crown ethers that transported potas-sium as successfully as valinomycin, and the synthesis of an antitubercular com-pound that resembled a transmembrane protein, all element to a organic inspira-tion.

The Organic Chemistry of Drug Synthesis, Volumes 1 to 4

Quantity four of this sequence is addressed basically at practitioners within the box who search a short review of the artificial routes that have been used to entry particular periods of healing brokers. This quantity covers the chemistry of these compounds which were granted a usa followed identify (USAN) within the 5 years among 1983 and 1987.

Extra info for Controlled-Release Technology. Pharmaceutical Applications

Example text

18. ; Eds. John Wiley and Sons: New York, 1985, pp. 407-432. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. Chapter 4 Estimation of Rates of Drug Diffusion in Polymers C. G. Pitt, A. L. Andrady, Y. T. Bao, and Ν. K. P. O. Box 12194, Research Triangle Park, NC 27709 A method of estimating the solubility of drugs in rub­ bery polymers, based on the octanol-water partition coefficient of the drug, is described. This method, when combined knowledge of the drug diffusion coef­ ficient D, permits calculation of diffusion controlled release rates.

For s m a l l p a r t i t i o n c o e f f i c i e n t s , ( Ρ )> ^ ^- S tinie f ° sin­ g l e o i l l a m i n a t e i s s h o r t compared t o t n e time t o change t h e c o n c e n ­ t r a t i o n o f t h e s u r r o u n d i n g water p h a s e s . C o n s e q u e n t l y , one e x p e c t s (a) t h e c o n c e n t r a t i o n p r o f i l e s a c r o s s each o i l b a r r i e r t o resemble s t e a d y s t a t e , ( i . e . , t h e c o n c e n t r a t i o n s h o u l d be a l i n e a r f u n c t i o n o f d i s t a n c e , ) and (b) t h e c o n c e n t r a t i o n i n each water phase s h o u l d almost be c o n s t a n t .

Similar correlations between D and permeate size have been established f o r larger organic solutes, using the molecular volume or molecular weight i n place of the molecular d i a meter (5,6). For example, the values of E. i n polystyrene f o r eight a l k y l and a r y l derivatives were proportional to their molecular volumes (Figure 3). As the size of the diffusant increases i t i s possible to use the molecular weight as an approximation of molecular volume. Thus, Baker and Lonsdale (Jj noted that there i s an approximate log-log relationship between the d i f f u s i o n c o e f f i c i e n t and molecular weights f o r halogenated paraffins i n polystyrene and azonapthalene dyes i n natural rubber (7-9).

Download PDF sample

Rated 4.11 of 5 – based on 28 votes