By Ping I. Lee and William R. Good (Eds.)
content material: assessment of controlled-release drug supply / Ping I. Lee and William R. reliable --
Microstructural versions for diffusive shipping in porous polymers / W. Mark Saltzman, Stephen H. Pasternak, and Robert Langer --
Diffusion in heterogeneous media / Bret Berner, J.C. Keister, and Eugene R. Cooper --
Estimation of charges of drug diffusion in polymers / C.G. Pitt, A.L. Andrady, Y.T. Bao, and N.K.P. Samuel --
Interpretation of drug-release kinetics from hydrogel matrices when it comes to time-dependent diffusion coefficients / Ping I. Lee --
Physicochemical types for percutaneous absorption / J. Hadgraft and Richard H. man --
floor chemical research of polymeric drug supply platforms through static secondary ion mass spectrometry (SSIMS) and SIMS imaging / M.C. Davies and A. Brown --
better strategy for measuring in vitro diffusion of substances via human dermis / L.R. Brown, J.F. Cline, C.L. Raleigh, and M.B. Henry --
Simplified process for measuring controlled-release kinetics / Charles G. Gebelein, Tahseen Mirza, and Robert R. Hartsough --
Thermally reversible gelation features : poly(oxyethylene)-poly(oxypropylene) block copolymer in aqueous resolution after publicity to high-energy irradiation / D. Attwood, C.J. Tait, and J.H. Collett --
unlock and behind schedule liberate of water-soluble medicinal drugs from polymer beads with low water swelling / Karl F. Mueller --
Morphine hydrogel suppositories : machine layout, scale-up, and overview / Marion E. McNeill and Neil B. Graham --
Use of bioerodible polymers in self-regulated drug supply structures / J. Heller, S.H. Pangburn, and D.W.H. Penhale --
Polysaccharides as drug providers : activation tactics and biodegradation reports / Etienne Schacht, Filip Vandoorne, Joan Vermeersch, and Ruth Duncan --
Microspheres as controlled-release structures for parenteral and nasal management / S.S. Davis, L. Illum, D. Burgess, J. Ratcliffe, and S.N. generators --
improving drug unencumber from polylactide microspheres through the use of base within the microencapsulation method / Jones W. Fong, Hawkins V. Maulding, George E. Visscher, Josephine P. Nazareno, and Jane E. Pearson --
results of ethanol at the shipping of [beta]-estradiol in hairless mouse dermis : comparability of experimental info with a brand new theoretical version / W.I. Higuchi, U.D. Rohr, S.A. Burton, P. Liu, J.L. Fox, A.H. Ghanem, H. Mahmoud, S. Borsadia, and William R. strong --
Probing the constitution of stratum corneum at the molecular point / ok. Knutson, S.L. Krill, W.J. Lambert, and W.I. Higuchi --
New liposomal supply procedure for managed drug unencumber / Victoria M. Knepp, Robert S. Hinz, Francis C. Szoka, Jr., and Richard H. man --
more suitable absorption of ionizable medicines from topical dosage types / Tsuneji Nagai and Toyoaki Ishikura --
Transdermal drug supply approach with greater dermis permeability / Yei W. Chien and Chia-Shun Lee --
solution to improve intranasal peptide supply / Lawrence S. Olanoff and Richard E. Gibson --
Transbuccal absorption of diclofenac sodium in a puppy version / C.D. Ebert, V.A. John, P.T. Beall, and K.A. Rosenzweig --
Constant-release diffusion structures : fee regulate through geometric configuration / K.G. Nelson, S.J. Smith, and R.M. Bennett --
Disposable controlled-release gadget for drug infusion / Paul Y. Wang, Mary C.Y. Lee, and should S.M. Smith.
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Extra info for Controlled-Release Technology. Pharmaceutical Applications
18. ; Eds. John Wiley and Sons: New York, 1985, pp. 407-432. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1987. Chapter 4 Estimation of Rates of Drug Diffusion in Polymers C. G. Pitt, A. L. Andrady, Y. T. Bao, and Ν. K. P. O. Box 12194, Research Triangle Park, NC 27709 A method of estimating the solubility of drugs in rub bery polymers, based on the octanol-water partition coefficient of the drug, is described. This method, when combined knowledge of the drug diffusion coef ficient D, permits calculation of diffusion controlled release rates.
For s m a l l p a r t i t i o n c o e f f i c i e n t s , ( Ρ )> ^ ^- S tinie f ° sin g l e o i l l a m i n a t e i s s h o r t compared t o t n e time t o change t h e c o n c e n t r a t i o n o f t h e s u r r o u n d i n g water p h a s e s . C o n s e q u e n t l y , one e x p e c t s (a) t h e c o n c e n t r a t i o n p r o f i l e s a c r o s s each o i l b a r r i e r t o resemble s t e a d y s t a t e , ( i . e . , t h e c o n c e n t r a t i o n s h o u l d be a l i n e a r f u n c t i o n o f d i s t a n c e , ) and (b) t h e c o n c e n t r a t i o n i n each water phase s h o u l d almost be c o n s t a n t .
Similar correlations between D and permeate size have been established f o r larger organic solutes, using the molecular volume or molecular weight i n place of the molecular d i a meter (5,6). For example, the values of E. i n polystyrene f o r eight a l k y l and a r y l derivatives were proportional to their molecular volumes (Figure 3). As the size of the diffusant increases i t i s possible to use the molecular weight as an approximation of molecular volume. Thus, Baker and Lonsdale (Jj noted that there i s an approximate log-log relationship between the d i f f u s i o n c o e f f i c i e n t and molecular weights f o r halogenated paraffins i n polystyrene and azonapthalene dyes i n natural rubber (7-9).