Combinatorial Peptide and Nonpeptide Libraries: A Handbook by Günther Jung

By Günther Jung

Reference on compound libraries of peptides, for researchers in natural synthesis, biochemistry, biotechnology, pharmacology, drugs, and scientific chemistry. large assurance of man-made techniques and applied sciences, mass spectrometry, and screening assays. forty seven members, 21 U.S.

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The sequence motifs of the MHC bound natural peptide libraries described in Chapter 9 can be determined successfully via assay: using synthetic peptide libraries as demonstrated in Chapter 12. g. MHC-Class I [5,6] and I1 [7, 81 molecules, proteasomes [9], peptide transporters [lo], and monoclonal antibodies, the use of synthetic peptide libraries was highly successful. Fine mapping of continuous epitopes of monoclonal antibodies using the pin enzyme-linked immuno assays (ELISA) [lo], or biotinylated peptides has revealed interesting results with respect to essential 01 nonreplacable amino acids within an epitope and the diversity allowed for other POsitions [61, 621.

Engl. 1993, 32, 1336-1339. [27] A. Bayer, S. Freund, G. Jung, Eur. J. Biochem. 1995, 234, 414-426. I281 P. Yorgey, J. Davignono, R. Kolter, Mol. Microbiol. 1993, 9, 897. (291 M. Skaugen, J. Nissen-Meyer, G. Jung, S. StevanoviC, K. Sletten, C. I. Mortvedt Abildgaard, I. F. Nes, J. Biol. Chem. 1994, 269, 27183-27185. (301 T. Kupke, C. Kempter, G. Jung, F. Gdtz, J. Biol. Chem. 1995, 270, 11282-11289. 131) B. Ottenwalder, T. Kupke, S. Brecht, V. Gnau, J. Metzger, G. Jung, F. Gdtz, Appl. Environm. Microbiol.

Stevanovic, V. Gnau, G. Jung, A. Melms, Int. Immunol. 1993,10, 1229- 1237). All isolated individual self-DeDtide linands and Dreviouslv reDorted T-helmr edtoDes fit to this seauence motif. 1 Synthetic Methods and the Variety of Peptide and Oligomer Libraries In addition to the complete review in Chapter 3, this introductory section is intented to give only a brief overview of the most essential characteristics of various peptide libraries and guides to the literature and corresponding chapters of this book.

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