Chromatographic Methods in Metabolomics by Tuulia Hyotylainen, Susanne Wiedmer, Roger M Smith, Tuulia

By Tuulia Hyotylainen, Susanne Wiedmer, Roger M Smith, Tuulia Hyötyläinen, Ian D Wilson, Katja Dettmer, Akiyoshi Hirayama, Tiina Sikanen, Matej Oresic

This is a necessary guide for any laboratory trying to embark on a metabolomics learn programme and comprises the basics of chromatography along the most recent advancements within the field.

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In the case of very polar metabolites such as carnitines. In LC analyses, UV chromophores and fluorophores are often introduced into sample molecules to increase their sensitivity to UV absorption and fluorescence detection. Also with MS detection, derivatization of the analytes can improve the selectivity and sensitivity of the detection. Benzoyl chloride, m-toluyl chloride and p-nitrobenzoyl chloride are reagents that can add a benzene ring to a solute molecule and turn it into a UV-absorbing compound.

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