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Day, N. P. , von Seidlein, L. (2010). Artemisinin resistance: Current status and scenarios for containment. Nature Reviews Microbiology 8, 272–280. 37. Anonymous: IB Interview. (2013). A conversation with Jay Keasling, PhD. Industrial Biotechnology 9, 152–155. 38. Martin, V. , Pitera, D. , Withers, S. , Newman, J. , Keasling, J. D. (2003). Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nature Biotechnology 21, 796–802. 39. Ro, D. , Paradise, E. , Fisher, K.
Mosqueira, V. C. F. (2010). Nanotechnology applied to the treatment of malaria. Advanced Drug Delivery Reviews 82, 562–575. 54. Scheffler, R. , Demain, A. , Gullo, V. P. (2013). Antimicrobials, drug discovery, and genome mining. Applied Microbiology and Biotechnology 97, 969–978. Chapter 3 Emerging Instrumental Methods for Antimicrobial Resistance and Virulence Testing Plamen A. 1 INTRODUCTION Drug-resistant strains of pathogenic microorganisms—from viruses to single-cellular eukaryotic parasites—are rapidly emerging and exacerbating public health problems in both the developed and the developing world .
With the aim of generating new, less toxic nystatin derivatives, Brautaset et al. , using genetic engineering, designed, purified, and tested four new nystatin derivatives with promising therapeutic effects. MALARIA 15 Van Minnebruggen et al. ” One of the approaches could be genome mining of different organisms—actinomycetes and fungi in particular. 8 Miscellaneous Antifungals An interesting fact is that ants cultivate fungi as a food source. The ants contain a fungal garden which, unfortunately for the ants, can be parasitized by other fungi that can destroy the garden.