Burger's Medicinal Chemistry and Drug Discovery, by Donald J. Abraham

By Donald J. Abraham

This is often quantity five: Chemotherapeutic brokers, of Burger's Medicinal Chemistry and Drug Discovery, sixth variation. This new quantity comprises serious new chapters on Molecular Biology of melanoma, man made Anti-angiogenic brokers and Selective Toxicities.To buy the complete 6 quantity set, please seek advice from ISBN 0-471-37032-0.For an entire checklist of articles and members in addition to loose pattern chapters from this new sixth version please stopover at: www.mrw.interscience.wiley.com/bmcdd

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Although lentiviruses also have an RNA genome, their advantage compared with other retroviruses is the ability to infect and stably integrate into nondividing cells. To create a safe gene transfer vector based on the HIV-1 genome, the genome was altered and mutated to produce replication-defective particles. Several studies, both in vitro and in vivo, have shown successful gene transfer, including transduction of non-dividing hematopoetic cells at high efficiencies (up to 90%) and stable gene expression in several target tissues of interest such as liver (8 weeks) and muscle and brain (6 months) with no detectable immune response (124).

In addition, cells overexpressing COX-2 secrete increased levels of angiogenic factors like VEGF and bFGF. COX-2 not only aids in invasion but also inhibits apoptosis by up-regulating Bcl-2. 'COX-2 has come under intensive study as a target for colon cancer prevention. Multiple studies have illustrated that COX-2 selective inhibitors suppress tumorigenesis in multiple intestinal neoplasia (Min) mice. COX-2 inhibitors also inhibit tumor cell growth in immunocompromised mice (109). The same phe- nomena has been illustrated in human chemoprevention trials.

Volved in growth, for example, are often overexpressed in tumor tissues compared with normal adjacent tissue from the same organ. It is imperative to elucidate which genes are overexpressed or down-regulated in tumors because these genes represent critical therapeutic targets. Researchers today generally concentrate on a few particular genes and study their regulation, expression, and downstream signaling using conventional molecular biology tools. With the onslaught of new genome data, and the development of the GeneChip, scientists are now able to study the expression levels of numerous genes simultaneously.

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