Biological Basis of Alcohol-Induced Cancer by Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B.

By Vasilis Vasiliou, Samir Zakhari, Helmut K. Seitz, Jan B. Hoek

In the hot years, an important quantity of study has emerged connecting the hyperlink among alcohol and melanoma. the sphere has quickly complex, particularly because the complicated connection among alcohol and melanoma has a number of particular sub components which are being investigated. This lawsuits quantity will comprise chapters established upon the presentation of the second overseas convention on Alcohol and melanoma in Colorado, 2013. a few of the themes discover the impacts of alcohol on: liver and breast melanoma; mobile signaling and melanoma; stem cells; biomarkers and metabolomics; aerodigestive cancers; melanoma and the immune method and more.

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Eur J Cancer 33:39–44 8. Sotiriou C, Puszati L (2009) Gene expression signatures in breast cancer. N Engl J Med 360:790–800 9. Cancer Genome Atlas Network (2012) Comprehensive molecular portraits of human breast tumours. Nature 490:61–70 10. Conzen SD (2008) Nuclear receptors and breast cancer. Mol Endocrinol 22:2215–2228 11. Visvader JE (2009) Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis.

Almost half of the East Asian population is deficient in the mitochondrial enzyme that metabolizes acetaldehyde, the first metabolite of alcohol and a suspect in breast carcinogenesis. Although the drinking history of breast cancer patients was not assessed in this study, this observation suggests that acetaldehyde metabolism may not be a dominant determinant in breast cancer risk. To test any association between acetaldehyde and breast cancer, the effect of alcohol consumption on breast cancer incidence rates was studied in 597 Chinese, Japanese, and Filipino women living in San Francisco– Oakland, Los Angeles, and Oahu, Hawaii [44].

69 was based on only 89 cases. Other cancer subtypes (ER+/PR− or ER−/PR−) did not show significant increases and were based on even lower incidence. Therefore, the conclusion of the authors that moderate drinking was associated with breast cancer is not supported by data. 18. The Women’s Health Initiative-Observational Study enrolled 87,724 postmenopausal women aged 50−79 years, without a history of breast cancer between 1993 and 1998, who self-reported their alcohol use histories [42]. In a follow-up through 2005, a total of 2,944 patients with invasive breast cancer were diagnosed.

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