Biodrug Delivery Systems: Fundamentals, Applications and by Mariko Morishita, Kinam Park

By Mariko Morishita, Kinam Park

Biodrug supply platforms: basics, functions and medical Development offers the paintings of a world staff of top specialists in drug improvement and biopharmaceutical technology who talk about the newest advances in biodrug supply platforms and linked options. The publication discusses elements of profitable formula, supply, and creation of biodrugs, which come with refined vegetation and intricate tactics, a well-trained and a professional employees, and correct qc. moreover, the authors examine:

  • ADME (Absorption, Metabolism, Distribution, and removing of biodrugs)
  • Directing and influencing the profitable improvement of at present advertised best-selling biodrugs
  • Routes of management
  • Mechanisms of biodrug absorption
  • Alternative chances for drug supply routes
  • Formulationson the industry from the viewpoint of body of workers thinking about biodrug development

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Additional info for Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development (Drugs and the Pharmaceutical Sciences)

Example text

3(A). The importance of antigen-specific internalization of therapeutic antibodies is also observed in species differences in their dose-dependent clearances. Figure 4 shows the dose-dependent clearance of Panitumumab, which is fully human mAb against human EGFR, in cynomolgus monkeys and mice after administration of single IV doses (15). In monkeys, the total clearance of panitumumab was much higher than that in mice at lower doses, and dosedependent saturation of the clearance was observed only in monkeys, while clearance was not changed regardless of the dose in mice.

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Delie F, Blanco-Prieto MJ. Polymeric particulates to improve oral bioavailability of peptide drugs. Molecules 2005; 10:65–80. 65. Veronese FM, Pasut G. PEGylation, successful approach to drug delivery. Drug Discov Today 2005; 10(21):1451–1458. 66. Veronese FM, Morpurgo M. Bioconjugation in pharmaceutical chemistry. Farmaco 1999; 54:497–516. 67. Soran H, Younis N. Insulin detemir: a new basal insulin analogue. Diabetes Obes Metab 2005; 8:26–30. 68. Knudsen LB, Nielsen PF, Huufeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

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