Advances in Immunology 50 by Frank J. Dixon

By Frank J. Dixon

The fiftieth quantity in a monographic sequence on immunology. one of the themes coated listed here are avian T-cell ontogeny, adoptive move of human lymphoid cells to seriously immuno-deficient mice and histamine-releasing components and cytokine-dependent activation of basophils and mast cells.

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Alternatively, one may argue that deletion of developing T cells by Vbse that work in concert with I-E are allowable, just as the absence of I-E is allowable, but that Vbse that delete developing T cells in association with I-A are not permissible just as I-A-negative mice have not been observed. The Vbse that associate with I-A may have too low an affinity for the Vp site on the TCR to cause frank deletion, as this effect would be too deleterious to the host. , 1989a,b, 1990). Thus, HLA-DQ is clearly competent to present bacterial toxic mitogens.

JANEWAY, JR. 1 . Positive Selection of Vp Selective Eleinents Several groups have reported the presence of mature T cells expressing TCHs encoded by a particular Vp gene segment at higher than anticipated levels in mice of certain MHC genotypes. This overselection b y MHC Inolecules may reflect positive selection events. Whether this is due to a role of Vbse, or whether it reflects utilization of the particular Vp to recognize a particular MHC molecule, is not yet clear in these systems. However, the data are sufficiently striking, and the involvement of1-I3 in some of these systems is sufficiently reminiscent of the activation and deletion characteristic of Vbse, that it s e e m likely that Vbse will play a role in this process.

The Response of CD4 T Cells As stated earlier, all Vbse described to date depend on class I1 MHC molecules and stimulate predominantly CD4 T cells. This applies to endogenous Vbse and bacterial toxic mitogens. At least in the mouse, anti-CD4 profoundly inhibits this response. Thus, the CD4 T cell is the predominant cell that proliferates in response to Vbse. 2 . The Response of CD8 T Cells As stated above, purified CD8 T cells in mice will not proliferate in response to Vbse, but the CD8 T cell blasts that appear after stimulation of whole spleen T cells are apparently Vbse selected because they bear the appropriate TCR.

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